The Project

The X Project is an international collaboration to discover genomics basis of shared and specialized traits in placental mammals. We invite researchers across the scientific community to use our data, and to join us in harnessing the power of comparative genomics as a tool for human medicine and biodiversity conservation.

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The Mammal Tree

The X Project created 131 new genome assemblies for a total of 130 mammalian species. (In case you’re wondering why those numbers aren’t exactly the same: we created assemblies for two different narwhals, one male, one female!)

Our project data are of two broad forms. Species-level data are available for all 131 of our new assemblies. Comparative data include inferences from across all 240 assemblies included in our alignment.

The Phylogenetic Approach

To find the assembly for your favorite species or set of species, navigate to the relevant position on our tree, and click on the link to download the 200 Mammals assembly from NCBI.

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The Data-Type Approach

To find the assembly for your favorite species or set of species, navigate to the relevant position on our tree, and click on the link to download the 200 Mammals assembly from NCBI.

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The Phenotype Approach

To find the assembly for your favorite species or set of species, navigate to the relevant position on our tree, and click on the link to download the 200 Mammals assembly from NCBI.

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The White Paper

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The Data

Zoonomia has compared 241 mammalian genomes to find sites that are strongly conserved across all mammals, suggesting functional importance. We find that ~4% sites are strongly conserved across mammals as illustrated in blue here, suggesting that that they perform some essential function.

Functionally important DNA comprises only about 10% of the mammalian genome, and the search for medically relevant genetic variants amounts to a needle-in-a-haystack search. One of the most powerful strategies for shrinking that haystack is to identify genomic positions unchanged across millions of years of evolution, suggesting that they are functionally important.

From The Field

Narwal

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Bumble Bat

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Solenodon

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Meet Our Scientists

To find the assembly for your favorite species or set of species, navigate to the relevant position on our tree, and click on the link to download the 200 Mammals assembly from NCBI.

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